A stretch of the northbound Antelope Valley (14) Freeway in Acton was closed for nearly five hours Friday due to an apparent wrong-way injury crash involving a vehicle and a big rig that caught fire.

The crash was reported at about 2:45 p.m. just south of Crown Valley Road, according to the California Highway Patrol, which could not immediately confirm a KNX 1070 Newsradio report that a wrong-way driver entered the northbound lanes and collided with the big rig.

Two people were reportedly transported to a hospital with injuries of unknown severity.

The crash sparked a quarter-acre brush fire that was quickly stopped, according to county fire officials.

All northbound lanes were closed as authorities conducted an investigation into the crash. Caltrans reported at about 7:35 p.m. that all lanes were reopened.

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