“Deadpool & Wolverine” has retained its box office crown for another week, grossing $15.1 million over the first three days of the four-day Labor Day weekend, according to industry estimates released Sunday.

By the end of the holiday weekend, the Marvel juggernaut will have surpassed $600 million domestically in its six weeks of release.

“Alien: Romulus” held onto second place with $9.3 million Friday through Sunday in its third weekend in North American theaters, Comscore reported.

“It Ends with Us,” a domestic violence drama starring Blake Lively — who is married to “Deadpool & Wolverine” star Ryan Reynolds — made another $7.42 million in its fourth weekend for third place.

“Reagan,” a biopic of the nation’s 40th president starring Dennis Quaid, opened with $7.4 million for fourth place, followed by “Twisters,” which took in $7.1 million in its seventh week.

Rounding out the top 10 domestic releases were “Blink Twice” ($4.68 million), “The Forge” ($4.6 million), “Despicable Me 4” ($4 million), “Afraid” ($3.7 million) and “Inside Out 2” ($2.7 million).

This weekend’s overall three-day box office haul was estimated at $81 million. The year-to-date total is $5.740 billion — down 14% from the figure at this time last year, according to Comscore.

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