A 20-year-old woman was arrested in connection with a four-vehicle crash Saturday in Sherman Oaks on the eastbound Ventura (101) Freeway that killed two people — including a 15-year-old boy.

Paramedics rushed the woman, a resident of Los Angeles, to Ronald Reagan UCLA Medical Center, where she was being treated for moderate injuries, the California Highway Patrol reported. The CHP said alcohol was determined to be a factor in the crash.

The woman was driving a 2008 Honda east of Van Nuys Boulevard when she rear-ended a 2019 Isuzu box truck at about 12:10 a.m., the CHP said. The impact caused both vehicles to careen toward the center divider wall.

The Isuzu entered the westbound lanes and was struck by a 2017 Honda.

A 2016 Dodge, also in the westbound lanes, was struck by concrete debris caused by the destruction of the center divider wall, the CHP said.

“The collision with the center divider wall, and subsequent collision from the 2017 Honda, caused significant intrusion to the passenger compartment of the Isuzu,” according to a CHP statement. “Two passengers from the Isuzu suffered fatal injuries as a result of the these collisions.”

A 40-year-old woman was pronounced dead at the scene. Paramedics rushed the 15-year-old boy to Ronald Reagan UCLA Medical Center, where he later died from his injuries, the CHP said.

The driver of the 2017 Honda, a 49-year-old woman from Reseda, was rushed to Ronald Reagan UCLA Medical Center with major injuries.

The two fatalities, as well as the motorist in the Isuzu — a 53-year-old man — were residents of Santa Maria.

The 37-year-old woman driving the 2016 Dodge escaped injury.

The CHP’s West Valley office urged anyone with information regarding the crash to call them at 818-888-0980.

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