Two people were killed and four others were injured in a fiery, multi-vehicle crash Saturday on the San Diego (405) Freeway in Westminster that involved a big rig and a pickup truck.

Two people were pronounced dead at the scene, Orange County Fire Authority Capt. Tony Bommarito said.

Paramedics rushed two trauma patients to UCI Medical Center in Orange and two other people with minor injuries to area hospitals, Orange County Fire Authority Capt. Steve Concialdi said.

“Impairment” might have a played a role in the crash, which allegedly was triggered by a motorist in a speeding black Honda, California Highway Patrol Officer Duane Graham said. The motorist was one of the two critically injured people taken to UCI Medical Center, Graham said.

The crash on the southbound freeway at the Beach Boulevard offramp occurred a little after 4 a.m., the California Highway Patrol reported.

A white Dodge pickup truck was in a ditch on the right shoulder of the freeway and another vehicle had “visible flames,” according to the CHP.

Coroner’s officials were called to the scene at 4:50 a.m.

A SigAlert was issued at 4:11 a.m. closing the southbound lanes of the 405, and was canceled at 9:49 a.m.

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