A man and woman were killed and three other people, including a 4-year-old boy, were injured in a wrong-way head-on crash early Tuesday involving a suspected drunk driver on the northbound Harbor (110) Freeway in the downtown Los Angeles area.

The crash was reported at about 2 a.m. near Ninth Street, according to the California Highway Patrol.

A Lexus SUV was driving southbound in the northbound lanes of the freeway when it crashed into a northbound Toyota sedan with two people inside, according to CHP Sgt. Jeff Lane, who added that alcohol was suspected as a factor in the crash.

According to the CHP, both occupants of the 1999 Toyota Camry died at the scene — a 21-year-old Downey man who was driving the car, and a 23-year-old Bellflower woman. The coroner’s office identified the woman as Jasmine Hope De La Cruz. The man’s name was withheld pending notification of his next of kin.

The 2006 Lexus RS400 was driven by a 32-year-old San Pedro man, who suffered major injuries. A 32-year-old woman and a 4-year-old boy, also San Pedro residents, were riding in the SUV and both suffered moderate injuries. All three were taken to a hospital. Their names were not released.

A short time after the collision, a Toyota Corolla crashed into the two vehicles, but that motorist was not injured, the CHP reported.

The Nos. 3, 4 and 5 lanes of the northbound 110 Freeway at Ninth Street and the transition roads from both directions of the Santa Monica (10) Freeway to the northbound 110 Freeway were closed until about 6:40 a.m., when all lanes and transition roads were reopened.

Anyone with information on the crash was urged to call the CHP Central Area Office at 213-744-2331 or 323-259-3200.

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