Conan O’Brien will begin filming his talk show Monday evening at the Largo at the Coronet, an intimate performance space on La Cienega Boulevard.

O’Brien — who had been filming remotely from his home with an iPhone and a laptop since the end of March — will continue interviewing guests via Zoom and without an audience.

A limited staff and crew will be on site in connection with government and industry health and safety protocols, with the remainder of the show’s production staff to continue working from home.

“I got started doing improv at the Coronet in 1986 and I’m glad we’ve figured out a way to safely keep that theater going during this lockdown,” O’Brien said in a statement released last week.

Will Farrell is O’Brien’s first scheduled guest of the week, followed by Rob Lowe on Tuesday, Lisa Kudrow on Wednesday and Jameela Jamil on Thursday.

Largo’s owner, Mark Flanagan, said he’s “so thrilled to partner with these fine people who will help vitally support our venue through these awful times.”

“Conan is an old friend and also happens to be a very gifted television person, brilliant comedian and open hearted human whose heart towers like his stature!,” Flanagan said in a statement released Monday morning. “We can breathe a little easier, and keep this boat afloat until we can see you all again.”

“Conan,” which airs at 11 p.m. on TBS Mondays through Thursdays, had been filmed at the Warner Bros. studio in Burbank before the coronavirus pandemic forced TV talk show hosts to begin filming remotely from their homes.

Meanwhile, O’Brien’s Team Coco on Thursday will also be launching a digital version of their monthly live stand-up show. “Team Coco Live: Moses Storm & Friends” will stream via Twitch and will feature well-known and up-and-coming comedians.

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