A 2 1/2-mile stretch of the Santa Ana (101) Freeway east of downtown Los Angeles will be closed again Friday night as weekend-long work continues on a project to replace the Sixth Street Viaduct.

Beginning at 10 p.m. Friday and continuing until 3 p.m. Sunday, the 101 Freeway will be closed between the Santa Monica (10) Freeway on the south and the “5/10/101” freeway interchange on the north.

It will be the second closure of the stretch to accommodate the work to remove the falsework on the aging structure. The freeway was also closed on the weekend of Oct. 22-24, but that planned 41-hour closure actually lasted only 26 hours, with crews completing their work ahead of schedule, according to the city Bureau of Engineering.

During the closure, drivers traveling westbound on the Pomona (60) Freeway from the Pomona area will not be able to access the 101 Freeway. Those drivers will be detoured north on the Long Beach (710) Freeway to the westbound 10/101 Freeway.

Southbound drivers on the 101 can take the Harbor (110) Freeway south, then head east on the Santa Monica (10) Freeway to bypass the closed freeway section.

“The Bureau of Engineering has completed installation of cable hangers along the arches above the 101 Freeway,” according to the city.

“That span is now fully supported and no longer requires the supporting falsework under the bridge. The contractor will remove the falsework during the closure.”

The work is part of the city’s $588 million Sixth Street Viaduct Replacement Project, replacing a 1930s-era structure that is considered seismically unsound. The new viaduct, set to be completed next summer, is the largest bridge project in city history.

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