Two people were killed and four others were injured in a fiery, multi-vehicle crash Saturday on the San Diego (405) Freeway in Westminster that involved a big rig and a pickup truck.

Two people were pronounced dead at the scene and four people were rushed to hospitals, where their conditions were not immediately known, Orange County Fire Authority Capt. Tony Bommarito said.

“Impairment” might have a played a role in the crash, which allegedly was triggered by a motorist in a speeding black Honda, California Highway Patrol Officer Duane Graham said.

The motorist was taken to an area hospital with serious injuries, Graham said.

The crash on the southbound freeway at the Beach Boulevard offramp occurred a little after 4 a.m., the California Highway Patrol reported.

A white Dodge pickup truck was in a ditch on the right shoulder of the freeway and another vehicle had “visible flames,” according to the CHP.

Coroner’s officials were called to the scene at 4:50 a.m.

A SigAlert, issued at 4:11 a.m. closing the Nos. 1, 2, 3 and 4 southbound lanes, with traffic being diverted at Goldenwest Street, was canceled at 9:49 a.m.

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